Home/GT Families/GT47/ext1a
ext1a
Danio rerio · Exostosin-1a (EC 2.4.1.224; 2.4.1.225)
GT47Model organism · annotation ≥ 4Fold GT-BInverting
External resources
Identification and annotation
| CAZy family | GT47 · CAZy entry |
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| Gene symbol | ext1a |
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| Synonyms / alternate names | - Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase 1a
- Multiple exostoses protein 1 homolog a
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| UniProt accession | Q5IGR8 |
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| NCBI Gene ID | not curated |
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| Source species | Danio rerio |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Exostosin-1a (EC 2.4.1.224; 2.4.1.225) |
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| Subcellular location | Endoplasmic reticulum membrane |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Inverting |
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| Cation dependence | Yes (Mn2+) |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | - UDP-N-acetyl-alpha-D-glucosamine
- UDP-alpha-D-glucuronate
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| Donor CCD code(s) | UD1, UGA |
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| Acceptor substrate(s) | - 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein]
- 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein]
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
730 aa
MQAKKRYLILFSAGVCLILLFYLQGPASRRTPKRGDDPHPHWPHFSDPLRAFIPWDQTETEDYNVRASPRHKRDDSTGADKCRMDSCFDFELCKRNGFKVYVYPQQKGEKISESYQNILSSIEGSRFYTSDPGQACLFVLNLDTLDRDQLSPQYVHNLKTKIQNLNLWNNGRNHLIFNLYSGTWPDYTEDLGFDIGQAMLAKASISTESFRPNFDISIPLFSKDHPRTGGERGFLKYNTIPPFRKYMLVFKGKRYLTGIGSDTRNALYHIHNAEDVVLLTTCKHGKDWQKHKDARCDKDNAEYDRYDYKEMLHNSTFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWELPFSEIIDWRTAAVIGDERLLLQIPSTVRSIHQDRILSLRQQTQFLWEAYFSSVEKIVLTTLEIIQDRVLQHSAHSTLMWNRLPGGLFTLPQYSSYLGDFPFFYALLGIKPHQKFTAVIHAVTPLVSQSQPIFKLLVAVAKSQFCAQIMVLWNCDKPLPSKHRWPATSVPVIVIEGESKVMSSRFLPYENIITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWDSNKERWGYTSKWTNDYSMVLTGAAFYHRYYNYLYTHYLPGSLKGLVDQLSNCEDILMNFLVSAVTKMPPIKVTQKKQYKETMMGQTSRASRWADPDHFAQRQTCMNKFASWFGTMPLVHSQMRLDPVLFRDQVSILRKKYRDIERL
Catalytic domain sequence
286 aa
RNGFKVYVYPQQKGEKISESYQNILSSIEGSRFYTSDPGQACLFVLNLDTLDRDQLSPQYVHNLKTKIQNLNLWNNGRNHLIFNLYSGTWPDYTEDLGFDIGQAMLAKASISTESFRPNFDISIPLFSKDHPRTGGERGFLKYNTIPPFRKYMLVFKGKRYLTGIGSDTRNALYHIHNAEDVVLLTTCKHGKDWQKHKDARCDKDNAEYDRYDYKEMLHNSTFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWELPFSEIIDWRTAAVIGDERLLLQIPSTVRSI
