Home/GT Families/GT6/Abo
Abo
Mus musculus · Histo-blood group ABO system transferase (EC 2.4.1.40; 2.4.1.37)
GT6Non-model organism · annotation 4–5Fold GT-ARetaining
External resources
Identification and annotation
| CAZy family | GT6 · CAZy entry |
|---|
| Gene symbol | Abo |
|---|
| Synonyms / alternate names | - Cis-AB transferase
- Fucosylglycoprotein 3-alpha-galactosyltransferase
- Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase
- Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase
- Glycoprotein-fucosylgalactoside alpha-galactosyltransferase
- Histo-blood group A transferase
- Histo-blood group B transferase
- NAGAT
|
|---|
| UniProt accession | P38649 |
|---|
| NCBI Gene ID | 80908 |
|---|
| Source species | Mus musculus |
|---|
| Taxonomic domain | Eukaryota |
|---|
| UniProt annotation level | 5 |
|---|
Function and localisation
| Enzyme function | Histo-blood group ABO system transferase (EC 2.4.1.40; 2.4.1.37) |
|---|
| Subcellular location | - Golgi apparatus, Golgi stack membrane
- Secreted
|
|---|
Structure and mechanism
| Fold type | GT-A |
|---|
| Catalytic mechanism | Retaining |
|---|
| Cation dependence | Yes (Mn2+) |
|---|
| Oligomeric state | not curated |
|---|
| PDB structures | not curated |
|---|
Donor and acceptor specificity
| Sugar nucleotide donor | - UDP-N-acetyl-alpha-D-galactosamine
- UDP-alpha-D-galactose
|
|---|
| Donor CCD code(s) | UD2, GDU |
|---|
| Acceptor substrate(s) | an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative |
|---|
| Acceptor CCD / GlycoCT | not curated |
|---|
Protein sequences
Full protein sequence
332 aa
MNLRGRPKCNFLHLGILPFAVFVLVFFGYLFLSFRSQNLGHPGAVTRNAYLQPRVLKPTRKDVLVLTPWLAPIIWEGTFNIDILNEQFRIRNTTIGLTVFAIKKYVVFLKLFLETAEQHFMVGHKVIYYVFTDRPADVPQVILGAGRQLVVLTVRNYTRWQDVSMHRMEMISHFSERRFLREVDYLVCADADMKFSDHVGVEILSTFFGTLHPGFYSSSREAFTYERRPQSQAYIPWDRGDFYYGGAFFGGSVLEVYHLTKACHEAMMEDKANGIEPVWHDESYLNKYLLYHKPTKVLSPEYLWDQQLLGWPSIMKKLRYVAVPKDHQAIRN
Catalytic domain sequence
289 aa
AVTRNAYLQPRVLKPTRKDVLVLTPWLAPIIWEGTFNIDILNEQFRIRNTTIGLTVFAIKKYVVFLKLFLETAEQHFMVGHKVIYYVFTDRPADVPQVILGAGRQLVVLTVRNYTRWQDVSMHRMEMISHFSERRFLREVDYLVCADADMKFSDHVGVEILSTFFGTLHPGFYSSSREAFTYERRPQSQAYIPWDRGDFYYGGAFFGGSVLEVYHLTKACHEAMMEDKANGIEPVWHDESYLNKYLLYHKPTKVLSPEYLWDQQLLGWPSIMKKLRYVAVPKDHQAIRN
