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GBGT1
Canis lupus familiaris · Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (EC 2.4.1.88)
GT6Non-model organism · annotation 4–5Fold GT-ARetaining
External resources
Identification and annotation
| CAZy family | GT6 · CAZy entry |
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| Gene symbol | GBGT1 |
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| Synonyms / alternate names | - FS
- Forssman glycolipid synthase
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| UniProt accession | Q95158 |
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| NCBI Gene ID | 403833 |
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| Source species | Canis lupus familiaris |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (EC 2.4.1.88) |
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| Subcellular location | Golgi apparatus membrane |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Retaining |
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| Cation dependence | Yes (Mn2+) |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-N-acetyl-alpha-D-galactosamine |
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| Donor CCD code(s) | UD2 |
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| Acceptor substrate(s) | - a globoside Gb4Cer (d18:1(4E))
- a globoside Gb4Cer
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
347 aa
MRCRRLALGLGFSLLSGIALWSLWIYMETWLPFSYVPYYLPCPEIFNMKLQYKGEKPFQPVTRSPHPQPKLLEQRPTELLTLTPWLAPIVSEGTFNPELLQHIYQPLNLTIGLTVFAVGKYTRFVQHFLESAEQFFMQGYQVYYYIFTNDPAGIPRVPLGPGRLLSIIPIQRHSRWEEISTRRMETISRHIAQRAHREVDYLFCVDVDMVFRNPWGPETLGDLVAAIHPGYYAVPRQQFPYERRHISTAFVAENEGDFYYGGAVFGGRVAKVYEFTTGCHMAILADKANGIMAAWQEESHLNRRFISHKPSKVLSPEYLWDDRKPQPPSLKLIRFSTLDKATSWLRS
Catalytic domain sequence
290 aa
FQPVTRSPHPQPKLLEQRPTELLTLTPWLAPIVSEGTFNPELLQHIYQPLNLTIGLTVFAVGKYTRFVQHFLESAEQFFMQGYQVYYYIFTNDPAGIPRVPLGPGRLLSIIPIQRHSRWEEISTRRMETISRHIAQRAHREVDYLFCVDVDMVFRNPWGPETLGDLVAAIHPGYYAVPRQQFPYERRHISTAFVAENEGDFYYGGAVFGGRVAKVYEFTTGCHMAILADKANGIMAAWQEESHLNRRFISHKPSKVLSPEYLWDDRKPQPPSLKLIRFSTLDKATSWLRS
