Home/GT Families/GT6/GGTA1
GGTA1
Bos taurus · N-acetyllactosaminide alpha-1,3-galactosyltransferase (EC 2.4.1.87)
GT6Non-model organism · annotation 4–5Fold GT-ARetaining28 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT6 · CAZy entry |
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| Gene symbol | GGTA1 |
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| Synonyms / alternate names | - UDP-galactose:beta-D-galactosyl-1
- 4-N-acetyl-D-glucosaminide alpha-1
- 3-galactosyltransferase
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| UniProt accession | P14769 |
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| NCBI Gene ID | 281780 |
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| Source species | Bos taurus |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | N-acetyllactosaminide alpha-1,3-galactosyltransferase (EC 2.4.1.87) |
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| Subcellular location | - Golgi apparatus
- Golgi stack membrane
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Retaining |
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| Cation dependence | Yes (Mn2+) |
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| Oligomeric state | not curated |
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| PDB structures | 1FG5, 1G8O, 1G93, 1GWV, 1GWW, 1GX0, 1GX4, 1K4V, 1O7O, 1O7Q, 1VZT, 1VZU, 1VZX, 2JCJ, 2JCK, 2JCL, 2JCO, 2VFZ, 2VS3, 2VS4, 2VS5, 2VXL, 2VXM, 2WGZ, 5NR9, 5NRB, 5NRD, 5NRE |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-galactose |
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| Donor CCD code(s) | GDU |
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| Acceptor substrate(s) | a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
368 aa
MNVKGKVILSMLVVSTVIVVFWEYIHSPEGSLFWINPSRNPEVGGSSIQKGWWLPRWFNNGYHEEDGDINEEKEQRNEDESKLKLSDWFNPFKRPEVVTMTKWKAPVVWEGTYNRAVLDNYYAKQKITVGLTVFAVGRYIEHYLEEFLTSANKHFMVGHPVIFYIMVDDVSRMPLIELGPLRSFKVFKIKPEKRWQDISMMRMKTIGEHIVAHIQHEVDFLFCMDVDQVFQDKFGVETLGESVAQLQAWWYKADPNDFTYERRKESAAYIPFGEGDFYYHAAIFGGTPTQVLNITQECFKGILKDKKNDIEAQWHDESHLNKYFLLNKPTKILSPEYCWDYHIGLPADIKLVKMSWQTKEYNVVRNNV
Catalytic domain sequence
297 aa
NEEKEQRNEDESKLKLSDWFNPFKRPEVVTMTKWKAPVVWEGTYNRAVLDNYYAKQKITVGLTVFAVGRYIEHYLEEFLTSANKHFMVGHPVIFYIMVDDVSRMPLIELGPLRSFKVFKIKPEKRWQDISMMRMKTIGEHIVAHIQHEVDFLFCMDVDQVFQDKFGVETLGESVAQLQAWWYKADPNDFTYERRKESAAYIPFGEGDFYYHAAIFGGTPTQVLNITQECFKGILKDKKNDIEAQWHDESHLNKYFLLNKPTKILSPEYCWDYHIGLPADIKLVKMSWQTKEYNVVRN
