Pomgnt2 (GT61)

Pomgnt2

Mus musculus · Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (EC 2.4.1.312)

GT61Non-model organism · annotation 4–5Fold GT-BInverting

External resources

UniProt Q8BW41 AlphaFold model InterPro domains NCBI Gene 215494 CAZy GT61

Identification and annotation

CAZy family	GT61 · CAZy entry
Gene symbol	Pomgnt2
Synonyms / alternate names	Ago61 Eogtl Gtdc2 Extracellular O-linked N-acetylglucosamine transferase-like Glycosyltransferase-like domain-containing protein 2
UniProt accession	`Q8BW41`
NCBI Gene ID	`215494`
Source species	Mus musculus
Taxonomic domain	Eukaryota
UniProt annotation level	5

Function and localisation

Enzyme function	Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (EC 2.4.1.312)
Subcellular location	Endoplasmic reticulum membrane

Structure and mechanism

Fold type	GT-B
Catalytic mechanism	Inverting
Cation dependence	No
Oligomeric state	not curated
PDB structures	not curated

Donor and acceptor specificity

Sugar nucleotide donor	UDP-N-acetyl-alpha-D-glucosamine
Donor CCD code(s)	`UD1`
Acceptor substrate(s)	3-O-(alpha-D-mannosyl)-L-threonyl-[protein]
Acceptor CCD / GlycoCT	not curated

Protein sequences

Full protein sequence

580 aa

MHLSAVFNALLVSVLAAVLWKHVRLREHAATLEEELALGQQSLDPVLGLKIDYPKALQILMEGGTHMVCTGRTHTDRICRFKWLCYSNEAEEFIFFHGNSSVMLPNLGSRRFQPALLDLSTVEDHNAQYFNFVELPAAALRFMPKPVFVPDVALIANRFNPDNLMHVFHDDLLPLFYTLRQFPGLAQEARLFFMEGWGEGAHFDLYKLLSPKQPLLRAQLKTLGRLLCFSHAFVGLSKVTTWYQYGFVQPQGPKANILVSGNEIRQFTRFMTERLNVSHAGAPLGEEYILVFSRTQNRLILNEAELLLELAQEFQMKTVTVSLEDHTFADVVRLVSNASMLVSMHGAQLVTALFLPRGATVVELFPYAVNPDHYTPYKTLATLPGMDLQYVAWRNMIRENTVTHPERPWDQGGITHLDRAEQARILQSREVPRHLCCRNPEWLFRIYQDTRVDIPSLMQSIRRVVKGRPGPRRQRWAISLYPGKVREARCQASVQGATEARLSVSWQIPWNLKYLKVREVKYEVWLQEQGENTYVPYMLTLQNHTFTENIKPFTTYLVWVRCIFNRSLLGPFADVLVCST

Catalytic domain sequence

99 aa

IRQFTRFMTERLNVSHAGAPLGEEYILVFSRTQNRLILNEAELLLELAQEFQMKTVTVSLEDHTFADVVRLVSNASMLVSMHGAQLVTALFLPRGATVV