Home/GT Families/GT7/B4GALT1
B4GALT1
Capra hircus · Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (EC 2.4.1.38; 2.4.1.90)
GT7Non-model organism · annotation 4–5Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT7 · CAZy entry |
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| Gene symbol | B4GALT1 |
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| Synonyms / alternate names | - N-acetyllactosamine synthase
- Nal synthase
- Neolactotriaosylceramide beta-1,4-galactosyltransferase
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| UniProt accession | E9NRZ3 |
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| NCBI Gene ID | 100860927 |
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| Source species | Capra hircus |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (EC 2.4.1.38; 2.4.1.90) |
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| Subcellular location | - Golgi apparatus
- Golgi stack membrane
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | Yes (Mn2+) |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-galactose |
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| Donor CCD code(s) | GDU |
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| Acceptor substrate(s) | - N-acetyl-D-glucosamine
- a beta-D-glucosylceramide
- a neolactoside IV(3)-beta-GlcNAc-nLc4Cer
- an N-acetyl-beta-D-glucosaminyl derivative
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
402 aa
MKFREPLLGGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLRRLPQLVGVRTTLQGSSHGAAAIGQPSGELRLRGAAPPPPLQNSSELRSRAASNPDADSRPGPGPGPGSNLTSAPVPSTTTLSLTECPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGRYSPTDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGMSVSRPNAVIGKCRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS
Catalytic domain sequence
219 aa
PHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGMSVSRPNAVIGKCRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYMVLEVQRYPLYTKITVD
