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Glycosyltransferase Curated Online Resource for Enzymology

Family-organised sequence, structure, mechanism and substrate-specificity records for the CAZy glycosyltransferases

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B4galt2

Mus musculus · Beta-1,4-galactosyltransferase 2 (EC 2.4.1.-; 2.4.1.38; 2.4.1.22; 2.4.1.90)

GT7Non-model organism · annotation 4–5Fold GT-AInverting

External resources

UniProt Q9Z2Y2AlphaFold modelInterPro domainsNCBI Gene 53418CAZy GT7

Identification and annotation

CAZy familyGT7 · CAZy entry
Gene symbolB4galt2
Synonyms / alternate names
  • Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
  • Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
  • Lactose synthase A protein
  • N-acetyllactosamine synthase
  • Nal synthase
  • UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2
  • UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2
UniProt accessionQ9Z2Y2
NCBI Gene ID53418
Source speciesMus musculus
Taxonomic domainEukaryota
UniProt annotation level5

Function and localisation

Enzyme functionBeta-1,4-galactosyltransferase 2 (EC 2.4.1.-; 2.4.1.38; 2.4.1.22; 2.4.1.90)
Subcellular location
  • Golgi apparatus
  • Golgi stack membrane

Structure and mechanism

Fold typeGT-A
Catalytic mechanismInverting
Cation dependenceYes (Mn2+)
Oligomeric statenot curated
PDB structuresnot curated

Donor and acceptor specificity

Sugar nucleotide donorUDP-alpha-D-galactose
Donor CCD code(s)GDU
Acceptor substrate(s)
  • D-glucose
  • an N-acetyl-beta-D-glucosaminyl derivative
  • N-acetyl-D-glucosamine
Acceptor CCD / GlycoCTnot curated

Protein sequences

Full protein sequence

369 aa 
MSRLLGGTLERVCKAVLLLCLLHFLVAVILYFDVYAQHLAFFSRFSTRSPAHALYPAASSSTNCSRPNATAASSGLPEVPSARPGPTAPVIPPCPDVPPGLVGRVVIEFTSPMPLERVQRENPGVLLGGRYSPPDCTPAQTVAVIIPFRHREHHLRYWLHYLHPMLRRQRLRYGVYVINQHGEETFNRAKLLNVGFLEALKEDAAYDCFIFSDVDLVPMDDRNLYRCGDQPRHFAIAMDKFGFRLPYASYFGGVSGLSKAQFLRINGFPNEYWGWGGEDDDIFNRISLTGMKISRPDVRIGRYRMIKHDRDKHNEPNPQRFNKIQNTKMSMKWDGIGSVRYRVLEVSRQPLFTNITVDIGQPMSWLTQG

Catalytic domain sequence

217 aa 
VAVIIPFRHREHHLRYWLHYLHPMLRRQRLRYGVYVINQHGEETFNRAKLLNVGFLEALKEDAAYDCFIFSDVDLVPMDDRNLYRCGDQPRHFAIAMDKFGFRLPYASYFGGVSGLSKAQFLRINGFPNEYWGWGGEDDDIFNRISLTGMKISRPDVRIGRYRMIKHDRDKHNEPNPQRFNKIQNTKMSMKWDGIGSVRYRVLEVSRQPLFTNITVD
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