GT-CORE (public beta v1)

Glycosyltransferase Curated Online Resource for Enzymology

Family-organised sequence, structure, mechanism and substrate-specificity records for the CAZy glycosyltransferases

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B4galt3

Mus musculus · Beta-1,4-galactosyltransferase 3 (EC 2.4.1.-; 2.4.1.38; 2.4.1.90; 2.4.1.275)

GT7Non-model organism · annotation 4–5Fold GT-AInverting

External resources

UniProt Q91YY2AlphaFold modelInterPro domainsNCBI Gene 57370CAZy GT7

Identification and annotation

CAZy familyGT7 · CAZy entry
Gene symbolB4galt3
Synonyms / alternate names
  • Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
  • Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
  • N-acetyllactosamine synthase
  • Nal synthase
  • Neolactotriaosylceramide beta-1,4-galactosyltransferase
  • UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3
  • UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3
UniProt accessionQ91YY2
NCBI Gene ID57370
Source speciesMus musculus
Taxonomic domainEukaryota
UniProt annotation level5

Function and localisation

Enzyme functionBeta-1,4-galactosyltransferase 3 (EC 2.4.1.-; 2.4.1.38; 2.4.1.90; 2.4.1.275)
Subcellular location
  • Golgi apparatus
  • Golgi stack membrane

Structure and mechanism

Fold typeGT-A
Catalytic mechanismInverting
Cation dependenceYes (Mn2+)
Oligomeric statenot curated
PDB structuresnot curated

Donor and acceptor specificity

Sugar nucleotide donorUDP-alpha-D-galactose
Donor CCD code(s)GDU
Acceptor substrate(s)
  • an N-acetyl-beta-D-glucosaminyl derivative
  • N-acetyl-D-glucosamine
  • a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))
  • a beta-D-glucosylceramide
  • a neolactoside IV(3)-beta-GlcNAc-nLc4Cer
Acceptor CCD / GlycoCTnot curated

Protein sequences

Full protein sequence

395 aa 
MLRRLLERPCTLALLVGSQLAVMMYLSLGGFRSLSALFGRDPGPTFDYSHPHDVYSNLSHLPAAPGAAGAPPAQALPYCPERSPFLVGPVSVSFSPVPSLAEIVERNPRVESGGRYRPAGCEPRSRTAIIVPHRAREHHLRLLLYHLHPFLQRQQLAYGIYVIHQAGNGTFNRAKLLNVGVREALRDEEWDCLFLHDVDLLPENDHNLYVCDPRGPRHVAVAMNKFGYSLPYPQYFGGVSALTPDQYLKMNGFPNEYWGWGGEDDDIATRVRLAGMKISRPPTSVGHYKMVKHRGDKGNEENPHRFDLLVRTQNSWTQDGMNSLTYRLLARELGPLYTNITADIGTDPRGPRSPSGPRYPPGSSQAFRQEMLQRRPPARPGPLPTANHTAPRGSH

Catalytic domain sequence

220 aa 
RSRTAIIVPHRAREHHLRLLLYHLHPFLQRQQLAYGIYVIHQAGNGTFNRAKLLNVGVREALRDEEWDCLFLHDVDLLPENDHNLYVCDPRGPRHVAVAMNKFGYSLPYPQYFGGVSALTPDQYLKMNGFPNEYWGWGGEDDDIATRVRLAGMKISRPPTSVGHYKMVKHRGDKGNEENPHRFDLLVRTQNSWTQDGMNSLTYRLLARELGPLYTNITAD
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