Home/GT Families/GT7/B4galt6
B4galt6
Rattus norvegicus · Beta-1,4-galactosyltransferase 6 (EC 2.4.1.-; 2.4.1.274)
GT7Non-model organism · annotation 4–5Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT7 · CAZy entry |
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| Gene symbol | B4galt6 |
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| Synonyms / alternate names | - Glucosylceramide beta-1,4-galactosyltransferase
- Lactosylceramide synthase
- UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6
- UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase
- UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6
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| UniProt accession | O88419 |
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| NCBI Gene ID | 65196 |
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| Source species | Rattus norvegicus |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Beta-1,4-galactosyltransferase 6 (EC 2.4.1.-; 2.4.1.274) |
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| Subcellular location | - Golgi apparatus
- Golgi stack membrane
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | Yes (Mn2+, Mg2+, Ca2+) |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-galactose |
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| Donor CCD code(s) | GDU |
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| Acceptor substrate(s) | a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
382 aa
MSALKRMMRVSNRSLIAFIFFFSLSTSCLYFIYVAPGIANTYLFMVQARGIMLRENVKTIGHMIRLYTNKNTTLNGTDYPEGNNTSDYLVQTTTYLPQNFTYSPHLPCPEKLPYMRGFLSVNVSEISFDEVHQLFSKDSEIEPGGHWRPQDCKPRWKVAVLIPFRNRHEHLPIFFLHLIPMLQKQRLEFAFYVIEQTGTQPFNRAMLFNVGFKEAMKDRAWDCVIFHDVDHLPENDRNYYGCGEMPRHFAAKLDKYMYILPYKEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNRVHYSGYNVTRPEGDLGKYTSIPHHHRGEVQFLGRYKLLRYSKERQFIDGLNNLLYTPKILVDRLYTNISVNLMPELAPVEDY
Catalytic domain sequence
217 aa
RWKVAVLIPFRNRHEHLPIFFLHLIPMLQKQRLEFAFYVIEQTGTQPFNRAMLFNVGFKEAMKDRAWDCVIFHDVDHLPENDRNYYGCGEMPRHFAAKLDKYMYILPYKEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNRVHYSGYNVTRPEGDLGKYTSIPHHHRGEVQFLGRYKLLRYSKERQFIDGLNNLLYTPKILVDRLYTNISVN
