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b4galt5
Danio rerio · Beta-1,4-galactosyltransferase 5 (EC 2.4.1.-; 2.4.1.274)
GT7Model organism · annotation ≥ 4Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT7 · CAZy entry |
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| Gene symbol | b4galt5 |
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| Synonyms / alternate names | - Beta-1,4-GalT II
- Glucosylceramide beta-1,4-galactosyltransferase
- Lactosylceramide synthase
- UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5
- UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5
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| UniProt accession | Q3YL68 |
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| NCBI Gene ID | 724080 |
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| Source species | Danio rerio |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Beta-1,4-galactosyltransferase 5 (EC 2.4.1.-; 2.4.1.274) |
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| Subcellular location | - Golgi apparatus, Golgi stack membrane
- Golgi apparatus
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | Yes (Mn2+) |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-galactose |
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| Donor CCD code(s) | GDU |
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| Acceptor substrate(s) | a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
381 aa
MPTHLRFRRRSFLGLLFLFSLSTSALYFIYSAPGIVNEYLFMVQARGIQIRENVRNMGAQVLEQVVRSAYSINGTDYTYEFNFSETDASPTPFLPEGFTYKPEQVCPEKLPSMKGRLKVNMSEIALDEVEKLLKLNDPGLSVGGHWKPHDCRPRWKVAILVPFRNRHEHLPILFRHLIPALQRQRLQFGFYVIEQAGNEPFNRAMLFNVGFKEAMKDLNWDCVIFHDVDHILENDRNYYGCGEMPRHFAVKLNKYSYMLPYEEFFGGVSGLTVKQFKRINGFPNAFWGWGGEDDDLWNRVQFAGYKVSRPHGELGRYMSIPHHHRGEVQFLGRYKLLRRSKERQSLDGLNNLNYSPLVSRRSLYTNVSVTLSRDLAPVADY
Catalytic domain sequence
216 aa
RWKVAILVPFRNRHEHLPILFRHLIPALQRQRLQFGFYVIEQAGNEPFNRAMLFNVGFKEAMKDLNWDCVIFHDVDHILENDRNYYGCGEMPRHFAVKLNKYSYMLPYEEFFGGVSGLTVKQFKRINGFPNAFWGWGGEDDDLWNRVQFAGYKVSRPHGELGRYMSIPHHHRGEVQFLGRYKLLRRSKERQSLDGLNNLNYSPLVSRRSLYTNVSV
