Home/GT Families/GT7/beta4GalNAcTB
beta4GalNAcTB
Drosophila melanogaster · Beta1,4-N-acetylgalactosaminyltransferase B (EC 2.4.1.244)
GT7Model organism · annotation ≥ 4Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT7 · CAZy entry |
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| Gene symbol | beta4GalNAcTB |
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| Synonyms / alternate names | - UDP-GalNAc:betaGlcNAc beta-1
- 4GalNAc-transferase
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| UniProt accession | Q9VAQ8 |
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| NCBI Gene ID | 43425 |
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| Source species | Drosophila melanogaster |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Beta1,4-N-acetylgalactosaminyltransferase B (EC 2.4.1.244) |
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| Subcellular location | - Golgi apparatus membrane
- Endoplasmic reticulum membrane
- Secreted
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | Yes (Mg2+) |
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| Oligomeric state | Interacts with GABPI; the interaction is required for locali |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-N-acetyl-alpha-D-galactosamine |
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| Donor CCD code(s) | UD2 |
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| Acceptor substrate(s) | - an N-acetyl-beta-D-glucosaminyl derivative
- a beta-D-GlcNAc-(1->3)-beta-D-Man-(1->4)-beta-D-Glc-(1<->1)-ceramide
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
323 aa
MFVRLWVRSFHKYDLLIAIGLITLIVYLCLPFRFASHYDYIEESKIEGALVPQVTRNVSQQEVFECTYSEIIAENRFVYHLAHYHDAVQRGAEIRPGGEFRPEGCQARYSTAIIVPYRQREEQLHAFLTYMHNYLPQQLIHYRIFLVEQFDHKPFNRAMLFNIGAQVAAEYGFPCLILHDVDLLPLNSGQIYACSERPRHMSSALDHWRFRLPYRGLFGGVVAINTAQYQQINGMSNLYYGWGGEDDDLYERLQALNIDICRFAMEFSKYTMLKHKQEQPNANRVALLRSATLRQHADGLNSLVYTEMERRMHSLFTHILVDT
Catalytic domain sequence
215 aa
RYSTAIIVPYRQREEQLHAFLTYMHNYLPQQLIHYRIFLVEQFDHKPFNRAMLFNIGAQVAAEYGFPCLILHDVDLLPLNSGQIYACSERPRHMSSALDHWRFRLPYRGLFGGVVAINTAQYQQINGMSNLYYGWGGEDDDLYERLQALNIDICRFAMEFSKYTMLKHKQEQPNANRVALLRSATLRQHADGLNSLVYTEMERRMHSLFTHILVD
