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bre-4
Caenorhabditis elegans · Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.244)
GT7Model organism · annotation ≥ 4Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT7 · CAZy entry |
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| Gene symbol | bre-4 |
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| Synonyms / alternate names | - Bacillus thuringiensis toxin-resistant protein 4
- Beta-4-GalNAcT
- UDP-GalNAc:Glc-NAcbeta-R beta1,4-N-acetylgalactosaminyltransferase
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| UniProt accession | Q9GUM2 |
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| NCBI Gene ID | 190668 |
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| Source species | Caenorhabditis elegans |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.244) |
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| Subcellular location | Membrane |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | Yes (Mn2+) |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-N-acetyl-alpha-D-galactosamine |
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| Donor CCD code(s) | UD2 |
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| Acceptor substrate(s) | an N-acetyl-beta-D-glucosaminyl derivative |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
383 aa
MAFRHLAVARLKSLLVLCAVLLLVHAMIYKIPSLYENLTIGSSTLIADVDAMEAVLGNTASTSDDLLDTWNSTFSPISEVNQTSFMEDIRPILFPDNQTLQFCNQTPPHLVGPIRVFLDEPDFKTLEKIYPDTHAGGHGMPKDCVARHRVAIIVPYRDREAHLRIMLHNLHSLLAKQQLDYAIFIVEQVANQTFNRGKLMNVGYDVASRLYPWQCFIFHDVDLLPEDDRNLYTCPIQPRHMSVAIDKFNYKLPYSAIFGGISALTKDHLKKINGFSNDFWGWGGEDDDLATRTSMAGLKVSRYPTQIARYKMIKHSTEATNPVNKCRYKIMGQTKRRWTRDGLSNLKYKLVNLELKPLYTRAVVDLLEKDCRRELRRDFPTCF
Catalytic domain sequence
219 aa
RHRVAIIVPYRDREAHLRIMLHNLHSLLAKQQLDYAIFIVEQVANQTFNRGKLMNVGYDVASRLYPWQCFIFHDVDLLPEDDRNLYTCPIQPRHMSVAIDKFNYKLPYSAIFGGISALTKDHLKKINGFSNDFWGWGGEDDDLATRTSMAGLKVSRYPTQIARYKMIKHSTEATNPVNKCRYKIMGQTKRRWTRDGLSNLKYKLVNLELKPLYTRAVVD
