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HAS3
Homo sapiens · Hyaluronan synthase 3 (EC 2.4.1.212)
GT2Model organism · annotation ≥ 4Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT2 · CAZy entry |
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| Gene symbol | HAS3 |
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| Synonyms / alternate names | - Hyaluronate synthase 3
- Hyaluronic acid synthase 3
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| UniProt accession | O00219 |
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| NCBI Gene ID | 3038 |
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| Source species | Homo sapiens |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Hyaluronan synthase 3 (EC 2.4.1.212) |
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| Subcellular location | - Cell membrane
- Golgi apparatus membrane
- Golgi apparatus, trans-Golgi network membrane
- Early endosome
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | Yes (Mg2+) |
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| Oligomeric state | Homodimers (PubMed:25795779). Forms heterodimers with HAS2 a |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | - UDP-N-acetyl-alpha-D-glucosamine
- UDP-alpha-D-glucuronate
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| Donor CCD code(s) | UD1, UGA |
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| Acceptor substrate(s) | - [hyaluronan](n)
- N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n)
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
553 aa
MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV
Catalytic domain sequence
279 aa
SVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKSYFRE
