Home/GT Families/GT2/glfT2
glfT2
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) · Galactofuranosyltransferase GlfT2 (EC 2.4.1.288)
GT2Non-model organism · annotation 4–5Fold GT-AInverting2 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT2 · CAZy entry |
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| Gene symbol | glfT2 |
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| Synonyms / alternate names | - glfT
- Arabinogalactan galactosyltransferase 2
- Galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase
- Polymerizing galactofuranosyltransferase GlfT2
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| UniProt accession | O53585 |
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| NCBI Gene ID | 886136 |
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| Source species | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
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| Taxonomic domain | Bacteria |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Galactofuranosyltransferase GlfT2 (EC 2.4.1.288) |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | Yes (Mn2+, Mg2+) |
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| Oligomeric state | homotetramer |
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| PDB structures | 4FIX, 4FIY |
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Donor and acceptor specificity
| Sugar nucleotide donor | 28 UDP-alpha-D-galactofuranose |
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| Donor CCD code(s) | not curated |
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| Acceptor substrate(s) | - beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans
- octa-cis-decaprenol
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
637 aa
MSELAASLLSRVILPRPGEPLDVRKLYLEESTTNARRAHAPTRTSLQIGAESEVSFATYFNAFPASYWRRWTTCKSVVLRVQVTGAGRVDVYRTKATGARIFVEGHDFTGTEDQPAAVETEVVLQPFEDGGWVWFDITTDTAVTLHSGGWYATSPAPGTANIAVGIPTFNRPADCVNALRELTADPLVDQVIGAVIVPDQGERKVRDHPDFPAAAARLGSRLSIHDQPNLGGSGGYSRVMYEALKNTDCQQILFMDDDIRLEPDSILRVLAMHRFAKAPMLVGGQMLNLQEPSHLHIMGEVVDRSIFMWTAAPHAEYDHDFAEYPLNDNNSRSKLLHRRIDVDYNGWWTCMIPRQVAEELGQPLPLFIKWDDADYGLRAAEHGYPTVTLPGAAIWHMAWSDKDDAIDWQAYFHLRNRLVVAAMHWDGPKAQVIGLVRSHLKATLKHLACLEYSTVAIQNKAIDDFLAGPEHIFSILESALPQVHRIRKSYPDAVVLPAASELPPPLHKNKAMKPPVNPLVIGYRLARGIMHNLTAANPQHHRRPEFNVPTQDARWFLLCTVDGATVTTADGCGVVYRQRDRAKMFALLWQSLRRQRQLLKRFEEMRRIYRDALPTLSSKQKWETALLPAANQEPEHG
Catalytic domain sequence
258 aa
NIAVGIPTFNRPADCVNALRELTADPLVDQVIGAVIVPDQGERKVRDHPDFPAAAARLGSRLSIHDQPNLGGSGGYSRVMYEALKNTDCQQILFMDDDIRLEPDSILRVLAMHRFAKAPMLVGGQMLNLQEPSHLHIMGEVVDRSIFMWTAAPHAEYDHDFAEYPLNDNNSRSKLLHRRIDVDYNGWWTCMIPRQVAEELGQPLPLFIKWDDADYGLRAAEHGYPTVTLPGAAIWHMAWSDKDDAIDWQAYFHLRNRL
