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tarS
Staphylococcus aureus (strain Mu50 / ATCC 700699) · Poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase TarS (EC 2.4.1.355)
GT2Model organism · annotation ≥ 4Fold GT-AInverting6 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT2 · CAZy entry |
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| Gene symbol | tarS |
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| Synonyms / alternate names | - Beta-O-GlcNAc transferase
- Beta-O-GlcNAc-WTA transferase
- WTA glycosyltransferase
- Wall teichoic acid beta-glycosyltransferase
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| UniProt accession | A0A0H3JPC6 |
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| NCBI Gene ID | not curated |
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| Source species | Staphylococcus aureus (strain Mu50 / ATCC 700699) |
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| Taxonomic domain | Bacteria |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase TarS (EC 2.4.1.355) |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | Yes (Mn2+) |
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| Oligomeric state | homotrimer |
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| PDB structures | 5TZ8, 5TZE, 5TZI, 5TZJ, 5TZK, 5U02 |
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Donor and acceptor specificity
| Sugar nucleotide donor | n UDP-N-acetyl-alpha-D-glucosamine |
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| Donor CCD code(s) | UD1 |
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| Acceptor substrate(s) | - 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans
- octa-cis-undecaprenyl diphosphate
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
573 aa
MMKFSVIVPTYNSEKYITELLNSLAKQDFPKTEFEVVVVDDCSTDQTLQIVEKYRNKLNLKVSQLETNSGGPGKPRNVALKQAEGEFVLFVDSDDYINKETLKDAAAFIDEHHSDVLLIKMKGVNGRGVPQSMFKETAPEVTLLNSRIIYTLSPTKIYRTALLKDNDIYFPEELKSAEDQLFTMKAYLNANRISVLSDKAYYYATKREGEHMSSAYVSPEDFYEVMRLIAVEILNADLEEAHKDQILAEFLNRHFSFSRTNGFSLKVKLEEQPQWINALGDFIQAVPERVDALVMSKLRPLLHYARAKDIDNYRTVEESYRQGQYYRFDIVDGKLNIQFNEGEPYFEGIDIAKPKVKMTAFKFDNHKIVTELTLNEFMIGEGHYDVRLKLHSRNKKHTMYVPLSVNANKQYRFNIMLEDIKAYLPKEKIWDVFLEVQIGTEVFEVRVGNQRNKYAYTAETSALIHLNNDFYRLTPYFTKDFNNISLYFTAITLTDSISMKLKGKNKIILTGLDRGYVFEEGMASVVLKDDMIMGMLSQTSENEVEILLSKDIKKRDFKNIVKLNTAHMTYSLK
Catalytic domain sequence
190 aa
VIVPTYNSEKYITELLNSLAKQDFPKTEFEVVVVDDCSTDQTLQIVEKYRNKLNLKVSQLETNSGGPGKPRNVALKQAEGEFVLFVDSDDYINKETLKDAAAFIDEHHSDVLLIKMKGVNGRGVPQSMFKETAPEVTLLNSRIIYTLSPTKIYRTALLKDNDIYFPEELKSAEDQLFTMKAYLNANRISV
