GT-CORE (public beta v1)

Glycosyltransferase Curated Online Resource for Enzymology

Family-organised sequence, structure, mechanism and substrate-specificity records for the CAZy glycosyltransferases

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waaA

Chlamydia trachomatis serovar D (strain ATCC VR-885 / DSM 19411 / UW-3/Cx) · 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.12; 2.4.99.13; 2.4.99.14)

GT30Non-model organism · annotation 4–5Fold GT-BInverting

External resources

UniProt P0CE14AlphaFold modelInterPro domainsNCBI Gene 884918CAZy GT30

Identification and annotation

CAZy familyGT30 · CAZy entry
Gene symbolwaaA
Synonyms / alternate names
  • gseA
  • kdtA
  • Kdo(2)-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase
  • Kdo-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase
  • Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase
  • Trifunctional Kdo transferase
UniProt accessionP0CE14
NCBI Gene ID884918
Source speciesChlamydia trachomatis serovar D (strain ATCC VR-885 / DSM 19411 / UW-3/Cx)
Taxonomic domainBacteria
UniProt annotation level4

Function and localisation

Enzyme function3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.12; 2.4.99.13; 2.4.99.14)
Subcellular locationnot curated

Structure and mechanism

Fold typeGT-B
Catalytic mechanismInverting
Cation dependenceNo
Oligomeric statenot curated
PDB structuresnot curated

Donor and acceptor specificity

Sugar nucleotide donorCMP-3-deoxy-beta-D-manno-octulosonate
Donor CCD code(s)not curated
Acceptor substrate(s)
  • lipid IVA (E. coli)
  • alpha-Kdo-(2->6)-lipid IVA (E. coli)
  • alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)
Acceptor CCD / GlycoCTnot curated

Protein sequences

Full protein sequence

431 aa 
MIRRWLTSRLYDAFLVCAFFVSAPRIFYKVFFHGKYIDSWKIRFGVQKPFVKGEGPLVWFHGASVGEVSLLAPLLNRWREEFPEWRFVVTTCSEAGVHTARRLYESLGATVFVLPLDLSCIIKSVVRKLAPDIVIFSEGDCWLHFLTESKRLGAKAFLINGKLSEHSCKRFSFLKRLGRNYFAPLDLLILQDELYKQRFMQIGISSDKIHVTGNMKTFIESSLATNRRDFWRAKLQISSQDRLIVLGSMHPKDVEVWAEVVSHFHNSSTKILWVPRHLEKLKEHAKLLEKAGILFGLWSQGASFRQYNSLIMDAMGVLKDIYSAADIAFVGGTFDPSVGGHNLLEPLQKEVPLMFGPYIYSQSVLAEKLREKEAGLSVNKETLLDVVTDLLQNEKNRQAYIEKGKSFLKQEENSFQQTWEILKSQITCMKI

Catalytic domain sequence

179 aa 
SWKIRFGVQKPFVKGEGPLVWFHGASVGEVSLLAPLLNRWREEFPEWRFVVTTCSEAGVHTARRLYESLGATVFVLPLDLSCIIKSVVRKLAPDIVIFSEGDCWLHFLTESKRLGAKAFLINGKLSEHSCKRFSFLKRLGRNYFAPLDLLILQDELYKQRFMQIGISSDKIHVTGNMKT
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