Home/GT Families/GT31/C1GalTA
C1GalTA
Drosophila melanogaster · Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122)
GT31Model organism · annotation ≥ 4Fold GT-AInverting1 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT31 · CAZy entry |
|---|
| Gene symbol | C1GalTA |
|---|
| Synonyms / alternate names | - Core 1 O-glycan T-synthase
- Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1
- Core 1 beta1,3-galactosyltransferase 1
|
|---|
| UniProt accession | Q7K237 |
|---|
| NCBI Gene ID | 34215 |
|---|
| Source species | Drosophila melanogaster |
|---|
| Taxonomic domain | Eukaryota |
|---|
| UniProt annotation level | 5 |
|---|
Function and localisation
| Enzyme function | Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) |
|---|
| Subcellular location | Membrane |
|---|
Structure and mechanism
| Fold type | GT-A |
|---|
| Catalytic mechanism | Inverting |
|---|
| Cation dependence | Yes (Mn2+) |
|---|
| Oligomeric state | homodimer |
|---|
| PDB structures | 7Q4I |
|---|
Donor and acceptor specificity
| Sugar nucleotide donor | UDP-alpha-D-galactose |
|---|
| Donor CCD code(s) | GDU |
|---|
| Acceptor substrate(s) | - an N-acetyl-alpha-D-galactosaminyl derivative
- a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]
- a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]
|
|---|
| Acceptor CCD / GlycoCT | not curated |
|---|
Protein sequences
Full protein sequence
388 aa
MTANSLLGRSILNEGRSNKRSFVSLIVGLIVGFCLAELFVYSTPERSEFMPYDGHRHGDVNDAHHSHDMMEMSGPEQDVGGHEHVHENSTIAERLYSEVRVLCWIMTNPSNHQKKARHVKRTWGKRCNKLIFMSSAKDDELDAVALPVGEGRNNLWGKTKEAYKYIYEHHINDADWFLKADDDTYTIVENMRYMLYPYSPETPVYFGCKFKPYVKQGYMSGGAGYVLSREAVRRFVVEALPNPKLCKSDNSGAEDVEIGKCLQNVNVLAGDSRDSNGRGRFFPFVPEHHLIPSHTDKKFWYWQYIFYKTDEGLDCCSDNAISFHYVSPNQMYVLDYLIYHLRPYGIINTPDALPNKLAVGELMPEIKEQATESTSDGVSKRSAETKTQ
Catalytic domain sequence
161 aa
IMTNPSNHQKKARHVKRTWGKRCNKLIFMSSAKDDELDAVALPVGEGRNNLWGKTKEAYKYIYEHHINDADWFLKADDDTYTIVENMRYMLYPYSPETPVYFGCKFKPYVKQGYMSGGAGYVLSREAVRRFVVEALPNPKLCKSDNSGAEDVEIGKCLQNV
