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PIGA
Homo sapiens · Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (EC 2.4.1.198)
GT4Model organism · annotation ≥ 4Fold GT-BRetaining
External resources
Identification and annotation
| CAZy family | GT4 · CAZy entry |
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| Gene symbol | PIGA |
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| Synonyms / alternate names | - GlcNAc-PI synthesis protein
- Phosphatidylinositol-glycan biosynthesis class A protein
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| UniProt accession | P37287 |
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| NCBI Gene ID | 5277 |
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| Source species | Homo sapiens |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (EC 2.4.1.198) |
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| Subcellular location | Rough endoplasmic reticulum membrane |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Retaining |
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| Cation dependence | No |
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| Oligomeric state | Component of the glycosylphosphatidylinositol-N-acetylglucos |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | UDP-N-acetyl-alpha-D-glucosamine |
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| Donor CCD code(s) | UD1 |
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| Acceptor substrate(s) | - a 1
- 2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)
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| Acceptor CCD / GlycoCT | INS Verified PDB CCD code |
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Protein sequences
Full protein sequence
484 aa
MACRGGAGNGHRASATLSRVSPGSLYTCRTRTHNICMVSDFFYPNMGGVESHIYQLSQCLIERGHKVIIVTHAYGNRKGIRYLTSGLKVYYLPLKVMYNQSTATTLFHSLPLLRYIFVRERVTIIHSHSSFSAMAHDALFHAKTMGLQTVFTDHSLFGFADVSSVLTNKLLTVSLCDTNHIICVSYTSKENTVLRAALNPEIVSVIPNAVDPTDFTPDPFRRHDSITIVVVSRLVYRKGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLIILCEPSVKSLCEGLEKAIFQLKSGTLPAPENIHNIVKTFYTWRNVAERTEKVYDRVSVEAVLPMDKRLDRLISHCGPVTGYIFALLAVFNFLFLIFLRWMTPDSIIDVAIDATGPRGAWTNNYSHSKRGGENNEISETR
Catalytic domain sequence
143 aa
RRHDSITIVVVSRLVYRKGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLIILCEPSVKSLCEGLEKAI
