Home/GT Families/GT4/QTMAN
QTMAN
Homo sapiens · tRNA-queuosine alpha-mannosyltransferase (EC 2.4.1.110)
GT4Model organism · annotation ≥ 4Fold GT-BRetaining
External resources
Identification and annotation
| CAZy family | GT4 · CAZy entry |
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| Gene symbol | QTMAN |
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| Synonyms / alternate names | - GTDC1
- Glycosyltransferase-like domain-containing protein 1
- Mannosyltransferase-like protein Xa
- Mat-Xa
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| UniProt accession | Q4AE62 |
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| NCBI Gene ID | 79712 |
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| Source species | Homo sapiens |
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| Taxonomic domain | Eukaryota |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | tRNA-queuosine alpha-mannosyltransferase (EC 2.4.1.110) |
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| Subcellular location | |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Retaining |
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| Cation dependence | No |
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| Oligomeric state | not curated |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | GDP-alpha-D-mannose |
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| Donor CCD code(s) | GDD |
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| Acceptor substrate(s) | queuosine(34) in tRNA(Asp) |
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
458 aa
MSILIIEAFYGGSHKQLVDLLQEELGDCVVYTLPAKKWHWRARTSALYFSQTIPISEHYRTLFASSVLNLTELAALRPDLGKLKKILYFHENQLIYPVKKCQERDFQYGYNQILSCLVADVVVFNSVFNMESFLTSMGKFMKLIPDHRPKDLESIIRPKCQVIYFPIRFPDVSRFMPKHKTTHLKKMLGLKGNGGAVLSMALPFQPEQRDSEDLLKNFNSECDTHCGLDTARQEYLGNSLRQESDLKKSTSSDNSSSHHGENKQNLTVDPCDILGGVDNQQRLLHIVWPHRWEHDKDPESFFKVLMHLKDLGLNFHVSVLGETFTDVPDIFSEAKKALGSSVLHWGYLPSKDDYFQVLCMADVVISTAKHEFFGVAMLEAVYCGCYPLCPKDLVYPEIFPAEYLYSTPEQLSKRLQNFCKRPDIIRKHLYKGEIAPFSWAALHGKFRSLLTTEPREDL
Catalytic domain sequence
130 aa
PHRWEHDKDPESFFKVLMHLKDLGLNFHVSVLGETFTDVPDIFSEAKKALGSSVLHWGYLPSKDDYFQVLCMADVVISTAKHEFFGVAMLEAVYCGCYPLCPKDLVYPEIFPAEYLYSTPEQLSKRLQNF
