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tarM
Staphylococcus aureus (strain COL) · Poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase (EC 2.4.1.70)
GT4Model organism · annotation ≥ 4Fold GT-BRetaining6 PDB structure(s)
External resources
Identification and annotation
| CAZy family | GT4 · CAZy entry |
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| Gene symbol | tarM |
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| Synonyms / alternate names | WTA GlcNAc-transferase |
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| UniProt accession | A0A0H2WWV6 |
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| NCBI Gene ID | not curated |
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| Source species | Staphylococcus aureus (strain COL) |
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| Taxonomic domain | Bacteria |
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| UniProt annotation level | 5 |
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Function and localisation
| Enzyme function | Poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase (EC 2.4.1.70) |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-B |
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| Catalytic mechanism | Retaining |
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| Cation dependence | No |
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| Oligomeric state | homotrimer |
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| PDB structures | 4WAC, 4WAD, 4X6L, 4X7M, 4X7P, 4X7R |
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Donor and acceptor specificity
| Sugar nucleotide donor | n UDP-N-acetyl-alpha-D-glucosamine |
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| Donor CCD code(s) | UD1 |
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| Acceptor substrate(s) | - 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans
- octa-cis-undecaprenyl diphosphate
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
493 aa
MKKIFMMVHELDVNKGGMTSSMFNRSKEFYDADIPADIVTFDYKGNYDEIIKALKKQGKMDRRTKMYNVFEYFKQISNNKHFKSNKLLYKHISERLKNTIEIEESKGISRYFDITTGTYIAYIRKSKSEKVIDFFKDNKRIERFSFIDNKVHMKETFNVDNKVCYQVFYDEKGYPYISRNINANNGAVGKTYVLVNKKEFKNNLALCVYYLEKLIKDSKDSIMICDGPGSFPKMFNTNHKNAQKYGVIHVNHHENFDDTGAFKKSEKYIIENANKINGVIVLTEAQRLDILNQFDVENIFTISNFVKIHNAPKHFQTEKIVGHISRMVPTKRIDLLIEVAELVVKKDNAVKFHIYGEGSVKDKIAKMIEDKNLERNVFLKGYTTTPQKCLEDFKLVVSTSQYEGQGLSMIEAMISKRPVVAFDIKYGPSDFIEDNKNGYLIENHNINDMADKILQLVNNDVLAAEFGSKARENIIEKYSTESILEKWLNLFNS
Catalytic domain sequence
165 aa
IHNAPKHFQTEKIVGHISRMVPTKRIDLLIEVAELVVKKDNAVKFHIYGEGSVKDKIAKMIEDKNLERNVFLKGYTTTPQKCLEDFKLVVSTSQYEGQGLSMIEAMISKRPVVAFDIKYGPSDFIEDNKNGYLIENHNINDMADKILQLVNNDVLAAEFGSKARE
