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ppm1
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) · Polyprenol monophosphomannose synthase (EC 2.4.1.-; 2.4.1.83)
GT2Non-model organism · annotation 4–5Fold GT-AInverting
External resources
Identification and annotation
| CAZy family | GT2 · CAZy entry |
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| Gene symbol | ppm1 |
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| Synonyms / alternate names | Dolichol-phosphate mannose synthase |
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| UniProt accession | A0QZ12 |
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| NCBI Gene ID | 93458598 |
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| Source species | Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) |
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| Taxonomic domain | Bacteria |
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| UniProt annotation level | 4 |
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Function and localisation
| Enzyme function | Polyprenol monophosphomannose synthase (EC 2.4.1.-; 2.4.1.83) |
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| Subcellular location | not curated |
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Structure and mechanism
| Fold type | GT-A |
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| Catalytic mechanism | Inverting |
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| Cation dependence | No |
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| Oligomeric state | Interacts with Lnt (also called Ppm2, AC A0QZ13) upon coexpr |
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| PDB structures | not curated |
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Donor and acceptor specificity
| Sugar nucleotide donor | GDP-alpha-D-mannose |
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| Donor CCD code(s) | GDD |
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| Acceptor substrate(s) | - a di-trans
- poly-cis-dolichyl phosphate
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| Acceptor CCD / GlycoCT | not curated |
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Protein sequences
Full protein sequence
265 aa
MSVPGEREQGAGEDPATVRPTQRTLVIIPTYNERENLPLIVGRVHHACPQVHILVVDDGSPDGTGALADELALADPDRVHVMHRTSKAGLGAAYLAGFDWGLRRGYSVLVEMDADGSHAPEELSRLLDAVDAGADLAIGSRYVPGGTVRNWPWRRLVLSKTANTYSRFLLGVGIHDITAGYRAYRREVLEKIDLSAVDSKGYCFQIDLTWRAINNGFSVVEVPITFTERELGVSKMSGSNIREAMFKVAEWGIRGRLDRARGVVR
Catalytic domain sequence
167 aa
VIIPTYNERENLPLIVGRVHHACPQVHILVVDDGSPDGTGALADELALADPDRVHVMHRTSKAGLGAAYLAGFDWGLRRGYSVLVEMDADGSHAPEELSRLLDAVDAGADLAIGSRYVPGGTVRNWPWRRLVLSKTANTYSRFLLGVGIHDITAGYRAYRREVLEKI
