NDP sugars and sugar derivatives

Nucleotide-sugar donors, sugar analogs and protected derivatives synthesised and purified by the BioF:GREAT laboratories. Compounds are purified using Teledyne CombiFlash preparative chromatography systems and supplied for use as donor substrates in glycosyltransferase reactions and chemoenzymatic synthesis.

Xylose compounds

Synthesised and purified in house, supplied at >95% purity as a white to off-white powder, with 1H NMR corresponding to the assigned structure. Store at −20 °C. Prices are per quantity of compound; select any compound to open a request form.

StructureCompoundFormula 2 mg5 mg10 mgNotes
Chemical structure: glucopyranose ring with a hydroxymethyl group, three hydroxyls and an azide at C-2. 2-Azido-2-deoxy-D-glucose
BUSJ001 · CAS 56883-39-7		 C6H11N3O5
205.17 g/mol		 $40 $75 $100 Deprotected azido-glucose for metabolic glycan labelling. The C-2 azide allows glucose utilisation to be tracked and supports site-specific bioconjugation by click chemistry. Request
Chemical structure: xylopyranose ring with three hydroxyls and a phosphate group at the anomeric position. D-Xylopyranose 1-phosphate
BUSJ002 · CAS 25799-81-9		 C5H11O8P
230.11 g/mol		 $350 $700 $1,100 An activated donor for enzymatic glycosylation, used to build xylo-oligosaccharides and UDP-sugar derivatives. Request
Chemical structure: xylopyranose ring with an azide at C-4 and three benzoyl-protected positions labelled OBz. 4-Azido-4-deoxy-1,2,3-tri-O-benzoyl-D-xylopyranoside
BUSJ003 · CAS —		 C26H21N3O7
487.47 g/mol		 $55 $120 $225 Benzoyl-protected azido-xylose for multi-step carbohydrate synthesis. The C-4 azide supports click conjugation or conversion to a 4-amino sugar; the protecting groups allow selective deprotection. Request
Chemical structure: xylopyranose ring with an azide at C-4 and hydroxyls at the remaining positions. 4-Azido-4-deoxy-D-xylopyranose
BUSJ004 · CAS —		 C5H9N3O4
175.14 g/mol		 $220 $450 $800 Deprotected azido-xylose with a free reducing end, for glycan synthesis, enzymatic modification and bioorthogonal labelling. Request
Chemical structure: xylopyranose ring with an azide at C-4 and a phosphate group at the anomeric position. 4-Azido-4-deoxy-D-xylopyranose 1-phosphate
BUSJ005 · CAS —		 C5H10N3O7P
255.12 g/mol		 $700 $1,100 Enquire Azido sugar phosphate carrying both a C-1 phosphate and a C-4 azide — a substrate for chemoenzymatic synthesis of UDP-xylose analogues and for bioorthogonal glycan labelling. Request

MurNAc compounds

These two compounds are in synthesis and will be available soon. No pricing or specification is published for them yet.

StructureCompoundFormula AvailabilityNotes
— UDP-MurNAc — Available soon Synthesis in progress; no pricing or specification is published yet. Register interest and we will be in touch when it is available. Enquire
— MurNAc-1-phosphate — Available soon Synthesis in progress; no pricing or specification is published yet. Register interest and we will be in touch when it is available. Enquire
Availability. This catalogue is expanding. For compounds not listed, custom syntheses or bulk quantities, use the compound request form or contact the BioF:GREAT team. Specification sheets with NMR spectra are available on request. See also the glycoenzyme catalogue for the recombinant enzymes that use these donors.