Internal projects
Internal projects are collaborations between BioF:GREAT laboratories at the University of Georgia. They span structural glycobiology, glycoproteomics, glycan engineering, computational method development and education research, and they exercise the same instrumentation and analytical pipelines available to external users through the User Facility.
Structural glycobiology
Multienzyme complexes in glycosaminoglycan synthesis
Lead laboratories: Moremen, Wells
Structural basis of a plant polysaccharide synthase
Lead laboratory: Moremen
Structure of a two-domain glycosyltransferase
Lead laboratories: Wood, Moremen
Structural basis of a polysaccharide backbone synthase Completed
Lead laboratory: Moremen
Glycoproteomics and modification mapping
Extracellular vesicle proteome
Lead laboratory: Wells
Glycoproteomic biomarker discovery in a cancer model
Lead laboratories: Wells, Berardinelli
Metabolic labelling to identify O-fucosylation substrates
Modification mapping on selected regulatory proteins
Lead laboratory: Wells
O-fucosylation in a soil amoeba
Lead laboratories: Wells, West
Secretome and interactome of proteoglycan-bearing cells
Lead laboratory: Wells
Secretome comparison in a glycosyltransferase knockout model
Lead laboratories: Wells, Berardinelli
Glycomics and analytical methods
NMR characterisation of defined glycan standards
Lead laboratory: Azadi
New fragmentation methods for glycan analysis
Lead laboratory: Azadi
Lectin-based detection of pathogen glycans Completed
Lead laboratory: Moremen
Linkage analysis of a defined glycan standard Completed
Lead laboratory: Azadi
Structural analysis of N-glycans in a model glycoprotein Completed
Lead laboratory: Azadi
Glycoenzyme expression and engineering
Xylosyltransferase characterisation
Lead laboratories: Moremen, Wells
Bacterial glycosyltransferase purification Completed
Lead laboratory: Wells
Computational and AI methods
AI tools for glycoenzyme annotation
Lead laboratory: Kannan
AI-assisted glycoenzyme design
Lead laboratories: Kannan, Moremen, Urbanowicz
Bioinformatic classification of viral lectin-like proteins
Lead laboratories: Azadi, Kannan
Evolution of a glycosylation pathway
Lead laboratories: Kannan, Urbanowicz
Machine-learning prediction of post-translational modifications
Lead laboratories: Kannan, Wells, Moremen
Machine-learning prediction of enzyme substrates Completed
Lead laboratory: Kannan
Structure prediction for glycans Completed
Lead laboratories: Moremen, Kannan
Education and outreach research
Classroom video assignment and pilot study
Lead laboratories: Dolan, Wells
Glycan tree of life resource
Lead laboratory: Dolan